The Doctrine of Original Antigenic Sin: Separating Good From Evil
Identifieur interne : 000266 ( Main/Exploration ); précédent : 000265; suivant : 000267The Doctrine of Original Antigenic Sin: Separating Good From Evil
Auteurs : Arnold S. Monto ; Ryan E. Malosh ; Joshua G. Petrie ; Emily T. MartinSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2017.
Abstract
The term “original antigenic sin” was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza virus strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness (VE). This conclusion was largely dismissed after an experimental study involving sequential administration of then-standard influenza vaccines. Recent observations have provided convincing evidence that reduced VE after sequential influenza vaccination is a real phenomenon. We propose that such reduction in VE be termed “negative antigenic interaction,” given that there is no age cohort effect. In contrast, the potentially positive protective effect of early influenza virus infection later in life continues to be observed. It is essential that we understand better the immunologic factors underlying both original antigenic sin and negative antigenic interaction, to support development of improved influenza vaccines and vaccination strategies.
Url:
DOI: 10.1093/infdis/jix173
PubMed: 28398521
PubMed Central: 5853211
Affiliations:
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Monto</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Malosh, Ryan E" sort="Malosh, Ryan E" uniqKey="Malosh R" first="Ryan E." last="Malosh">Ryan E. Malosh</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petrie, Joshua G" sort="Petrie, Joshua G" uniqKey="Petrie J" first="Joshua G." last="Petrie">Joshua G. Petrie</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Emily T" sort="Martin, Emily T" uniqKey="Martin E" first="Emily T." last="Martin">Emily T. Martin</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The term “original antigenic sin” was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza virus strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness (VE). This conclusion was largely dismissed after an experimental study involving sequential administration of then-standard influenza vaccines. Recent observations have provided convincing evidence that reduced VE after sequential influenza vaccination is a real phenomenon. We propose that such reduction in VE be termed “negative antigenic interaction,” given that there is no age cohort effect. In contrast, the potentially positive protective effect of early influenza virus infection later in life continues to be observed. It is essential that we understand better the immunologic factors underlying both original antigenic sin and negative antigenic interaction, to support development of improved influenza vaccines and vaccination strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Francis, T" uniqKey="Francis T">T Francis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name></author><author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M Ambrose</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO 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Hensley</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Malosh, Ryan E" sort="Malosh, Ryan E" uniqKey="Malosh R" first="Ryan E." last="Malosh">Ryan E. Malosh</name><name sortKey="Martin, Emily T" sort="Martin, Emily T" uniqKey="Martin E" first="Emily T." last="Martin">Emily T. Martin</name><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><name sortKey="Petrie, Joshua G" sort="Petrie, Joshua G" uniqKey="Petrie J" first="Joshua G." last="Petrie">Joshua G. Petrie</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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